The following is a partial list of notable players expected to compete in the 2010 U.S. Senior Open.

Fred Couples
Tom Lehman
Chip Beck
John Cook
Ben Crenshaw
Raymond Floyd
Fred Funk
Jay Haas
Scott Hoch
Hale Irwin
Peter Jacobsen
Tom Kite
Bernhard Langer
Sandy Lyle
Larry Mize
Larry Nelson
Greg Norman
Mark O’Meara
Loren Roberts
Jeff Sluman
Scott Simpson
Craig Stadler
Curtis Strange
Tom Watson
Ian Woosnam
Fuzzy Zoeller